Tramezzini NYC was born in 2015 when brothers Filippo and Massimiliano Paccagnella, from Pianiga in the Veneto region, set out to bring one of Italy's most underappreciated food rituals to New York City. The idea was simple: the tramezzino, the soft crustless Venetian sandwich eaten daily across northern Italy, had no real home in America.

In 2016, Tramezzini NYC debuted at Smorgasburg as the first brand in the United States to import authentic tramezzini bread from the Venetian countryside. That same year, they trademarked the name in the US. The press followed: New York Times, Bloomberg, Thrillist, Gothamist, and Food and Wine Italia.

In 2023, they closed the Lower East Side storefront to focus on catering and events, in partnership with Creminis NYC, a Brooklyn restaurant rooted in the regional cuisine of Le Marche. The New York Times covered it in January 2025 as "Venice meets Le Marche," a long-term pop-up uniting both regional identities under one concept.

Today Tramezzini NYC brings the Italian aperitivo ritual to private events, corporate gatherings, fashion activations, and rooftop experiences across New York, with expansion into Miami and Connecticut underway.